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Keep Calm and Contract Your Cytometry

Posted on: December 11, 2019

Top 5 Things to Look for in a Flow Cytometry CRO

There comes a moment when the flow cytometry work can be too much. Sometimes it’s the big “make-or-break” experiment that has to go just right, or sometimes it’s the monthly batches of clinical trial samples that have to be handled, on a Saturday, with swift, deft hands, and you’re the only one qualified for the job. That’s when you either break down in tears of exhaustion and frustration, or you consider finding some help. Now most investigators aren’t in a position to hire and train new staff for cytometry work, but there is high quality and reliable alternative - A contract research organization (CRO).

A CRO can carry out your flow cytometry experiments, to you exact specifications, and meet your needs for a single experiment or a multi-year clinical trial. CROs specializing in flow cytometry may be your best option to guarantee high quality and reliable results.

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To Validate or Not Validate... That Is The Assay Validation Question

Posted on: November 27, 2019

Many scientists performing preclinical and clinical research hit a point when they need to have an assay validated. You may have painstakingly developed and perfected a particular assay, but now you must put it through the rigors of validation for it to be considered a “validated assay.” The basic principles of assay validation were described in an earlier blog post, but how do you know you if you need an assay validated? Use these questions as a guide to help you figure out your validation situation and get a little less vexed about validation.

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Data Dive - Wrangling Big Data Sets from Flow Cytometry

Posted on: November 20, 2019

Advances in immunology data analysis have taken this field into the realm of “Big Data.” Flow cytometers can now measure dozens of parameters, and complementary techniques like mass cytometry can deliver data that requires sophisticated data analysis methods. Modern data analysis approaches have also revolutionized personalized immunotherapy and improved diagnostics.

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Preclinical Toxicology and Clinical Studies - Using Flow Cytometry throughout Development

Posted on: November 13, 2019

The pursuit of better medicine may take many years because of the complicated and often indirect path of biomedical research. Do you find yourself confused or unclear about when to use flow cytometry in “bench-to-bedside” research? The key is to understand the differences between preclinical and clinical research.

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Cytokine Release Syndrome and CAR-T cells: Challenges to Cutting-Edge Therapies

Posted on: November 07, 2019

Personalized cancer treatments, particularly chimeric antigen receptor (CAR) T cell therapy, have revolutionized the treatment of blood cancers and solid tumors. CAR T cell-based treatments use genetically modified T cells from a patient that are engineered to express a modified T cell receptor, which includes an extracellular binding domain that binds specifically to a patient’s tumor antigen, a transmembrane domain, and an intracellular domains that has multiple costimulatory domains (i.e., CD28, 4-1BB). Patients typically undergo lymphodepletion chemotherapy and are infused with their specific CAR -T cells, which are activated upon encounter with tumor antigen and can proliferate and lyse tumor cells. Although this type of treatment has been shown to be very effective for treating a wide range of tumors, severe side effects can occur, including cytokine release syndrome (CRS). Flow cytometry is a critical tool for understanding CRS and identifying biomarkers that may predict the onset of this complication.

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