With the advancement in biological drug development for therapeutic applications in the fields of infectious disease, autoimmunity and oncology, understanding the mechanism of action is critical for the rational design of therapies for enhanced immune activity.
Antibody Dependent Cell Phagocytosis
This describes the mechanism by which antibody opsonized target cells activate the FcRs on the surface of macrophages to induce phagocytosis.
Antibody Dependent Cell Cytotoxicity
The functional evaluation of the engagement and activity of effector cells against cancer cells, or infected cells bridges both the adaptive and innate immune responses.
CDC is the mechanism by which cells coated by antibodies activate the complement pathway, resulting in cell death.
FlowMetric has developed CDC approaches for a number of clinical applications including:
Safe dose ranges for cytotoxic drugs and the assessment of xeno-transplants. Our fit-for-purpose approach to assay development will ensure rapid and sensitive assessment of CDC.
Our expertise and commitment in hypothesis-driven analytical assessment of mechanism of action provides a robust and cost-effective approach to your MOA initiatives.